2. Drugs 67 (2007): 1027-1052, 4. J01DH02 - meropenem ; Belongs to the class of carbapenems. Diarrhea 4. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. A Skin Rash 2. Clin Infect Dis 24 Suppl 2 (1997): s197-206, 7. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. It is the same drug class as Imipenem. Drugs 68 (2008): 803-38, 5. Amikacin can be stored at room temperature and is stable for up to 2 years. Meropenem. Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis.  |  Meropenem - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Video Medindia No information is available on the effects of meropenem on the breast-fed child or on milk production. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. Eur J Drug Metab Pharmacokinet. Clipboard, Search History, and several other advanced features are temporarily unavailable. Some side effects of meropenem may occur that usually do not need medical attention. Diarrhea. 1997 Feb;24 Suppl 2:S266-75. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. Am J Health Syst Pharm 69 (2012): 1109, 19. 2019 Jun;44(3):433-436. doi: 10.1007/s13318-018-0524-4. Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." The dose was 2000 mg every 8 h for all patients, except for those with adverse drug effects or renal impairment (creatinine clearance [CrCL] ≤50 ml/minute), for whom the dose was reduced to 1000 mg every 8 h at the discretion of the attending … Drugs. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. References. These side effects may go away during treatment as your body adjusts to the medicine. Headache 5. Anemia If experienced, these tend to have a Less Severe expression 1. Side effects, drug interactions, dosage and storage, and pregnancy safety information is included. Meropenem. The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. Demographic data are included in Table Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. Medically reviewed by Drugs.com. Nausea 6. Kempf P, Bauernfeind A, Muller A, Blum J "Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections." has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. doi: 10.1093/clinids/24.supplement_2.s266. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Side effects. Sign up now. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. This medicine helps most people with infections, but it may have unwanted side effects in a few people. Get the latest public health information from CDC: https://www.coronavirus.gov. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Sometimes they are serious, most of the time they are not. 2016 Sep;5(9):475-83. doi: 10.1002/psp4.12101. Clin Infect Dis 36 (2003): E149-E151. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Read the side effects of Meropenem as described in the medical literature. You may need medical attention if you get some of the side effects. Share this conversation. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). USA.gov. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. Side Effects; Products and services. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. CPT Pharmacometrics Syst Pharmacol. Wilson SE "Results of a randomized, multicenter trial of meropenem versus clindamycin/tobramycin for the treatment of intra-abdominal infections." General Description: Meropenem. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. eCollection 2019 Jun. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. Clin Pharmacokinet. Serious side effects include Clostridium difficile infection, seizures, and allergic reactions including anaphylaxis. O 0, 14. In case of any doubt consult your doctor or pharmacist. Drug information provided by: IBM Micromedex. Clin Infect Dis. 2016. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion vous sera administré en injection ou en perfusion dans une grosse veine. Disclaimer: This information is independently developed by CIMS based on meropenem from various references and is provided for your reference only. Antimicrob Agents Chemother 42 (1998): 1233-8, 8. 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. Liu TJ, Lam JP "Piperacillin-tazobactam-induced acute interstitial nephritis with possible meropenem cross-sensitivity in a patient with osteomyelitis." Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. J Antimicrob Chemother. Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. PLoS Comput Biol. 1985 Jul-Aug;7 Suppl 3:S447-51. COVID-19 is an emerging, rapidly evolving situation. Free E-newsletter Subscribe to Housecall. What are some other side effects of Meropenem? Please enable it to take advantage of the complete set of features! Rev Infect Dis. Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Crit Care Med 30 (2002): 2580-3, 20. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. All medicines can have side effects. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Satisfied Customers: 7,210. Cerner Multum, Inc. "Australian Product Information." [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Seizures occurred more often in patients with moderately severe renal dysfunction. Merrem IV; Descriptions. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. Meropenem Study Group." J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. Infection 24 (1996): 480-4, 10. Therapeutic Effects: Bactericidal action against susceptible bacteria. This is especially important if your pet is currently taking probenecid. US Brand Name. Imipenem/cilastatin: rationale for a fixed combination. 1. Side effects of Merrem include nausea, vomiting, diarrhea, constipation, headache, or soreness, redness, or swelling at the injection site. 1.  |  All drugs may cause side effects. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males. Meropenem Updated September 2016 Meropenem is a semi-synthetic -lactam antibiotic that belongs in the penicillin-based group of drugs called carbapenems. "Comparative Review of the Carbapenems." Applies to meropenem: intravenous powder for solution. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Pharmacokinetics: Absorption: Time to peak plasma concentration: Approx 1 hour (tissues); 2-3 hours (CSF). Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. If experienced, these tend to have a Severe expression 1. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. Answered in 15 minutes by: 12/5/2010. Ask Your Own Veterinary Question. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Those who are allergic to other β-lactam antibiotics are more likely to be allergic to meropenem as well. Clin Ther 28 (2006): 1164-74, 6. Used in the systemic treatment of infections. Meropenem (Merrem) use in cats, is it safe? Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Therefore, inform your veterinarian of any and all medications your pet may be taking. Paquet P, Jacob E, Damas P, Pierard GE "Recurrent fatal drug-induced toxic epidermal necrolysis (Lyell's syndrome) after putative beta-lactam cross-reactivity: Case report and scrutiny of antibiotic imputability." Therapeutic uses, prescribing information and product availability may vary between countries. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Zhanel GG, Wiebe R, Dilay L, et al. You may report side effects to Health Canada at 1-866-234-2345. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Merrem (meropenem)." In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. infections in cystic fibrosis patients." [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. Cerner Multum, Inc. "UK Summary of Product Characteristics." Meropenem may also interact with some other medications. Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. Storage of the Drug. Side effects not requiring immediate medical attention. You may report them to the FDA. Carbapenem resistance is a growing problem in human medicine and is expecte… 5 mg/kg PO q24h (cats)10–20 mg/kg q24h (dogs) ... Meropenem: 8.5 mg/kg SC/IV q 12 (SC) or 8 (IV)h: Reserve for treatment of multidrug-resistant infections, particularly those caused by Enterobacteriaceae or Pseudomonas aeruginosa. Infection 24 (1996): 473-9, 11. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. This site needs JavaScript to work properly. Tell your doctor as soon as possible if you do not feel well while you are receiving meropenem. [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Meropenem is generally well tolerated by the central nervous system. NIH doi: 10.1093/clinids/7.supplement_3.s447. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. General Description: Meropenem. Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. eCollection 2019. Description: Meropenem is a β-lactam antibiotic. Last updated on Jul 26, 2020. Available for Android and iOS devices. Papich, MG, Riviere, JE. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Get the latest research from NIH: https://www.nih.gov/coronavirus. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Byrne S, Maddison J, Connor P, Doughty I, Dodd M, Jenney M, Webb AK, David TJ "Clinical evaluation of meropenem versus ceftazidime for the treatment of Pseudomonas spp. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. J Antimicrob Chemother 36(suppl a (1995): 145-56, 15. In the United States, amikacin is not FDA-approved for use in cattle or other food animals. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Three dogs were excluded from the age count because of an unknown birth date. Spectrum: Active against the following gram-positive organisms: Staphylococcus aureus, Streptococcus pneumoniae, Viridans group streptococci, Enterococcus faecalis. 1. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. O 0, 3. Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. "Product Information. Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Kimberly A. Toussaint, Jason C. Gallagher, in Side Effects of Drugs Annual, 2014. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The pharmacokinetic parameter … Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. Constipation 3. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. From: Side Effects of Drugs Annual, 2011. Therefore, unlike imipenem, meropenem can be used without dehydropeptidase inhibitors to obtain a consistently high concentration in the urine without nephrotoxic effects. Meropenem injection may cause side effects. Germovsek E, Lutsar I, Kipper K, Karlsson MO, Planche T, Chazallon C, Meyer L, Trafojer UMT, Metsvaht T, Fournier I, Sharland M, Heath P, Standing JF; NeoMero Consortium. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. doi: 10.1093/clinids/24.supplement_2.s249. Vomiting Meropenem. Seizures and other adverse CNS experiences have been reported. These side effects may go away during treatment as your body adjusts to the medicine. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. NLM Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." HHS However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. Meropenem has been reported to be excreted in human milk. The pharmacology of meropenem, a new carbapenem antibiotic. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Upset stomach or throwing up. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects in some animals. Baldwin CM, Lyseng-Williamson KA, Keam SJ "Meropenem : a review of its use in the treatment of serious bacterial infections." Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. However, many people have no side effects or only have minor side effects. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." COPD Study Group." Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. doi: 10.1371/journal.pcbi.1007117.  |  Category: Veterinary. Sepúlveda RA, Downey P, Soto D, Wong KY, Leung YC, So LY, Andresen M. Biomed Res Int. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction. Meropenem injection is used to treat infections caused by bacteria. Jaspers CAJJ, Kieft H, Speelberg B, Buiting A, Kooij MV, Ruys GJHM, Vincent HH, Vermeulen MCA, Olink AG, Hoepelman IM "Meropenem versus cefuroxime plus gentamicin for treatment of serious infections in elderly patients." Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. Verscheijden LFM, Koenderink JB, de Wildt SN, Russel FGM. Meropenem. Some side effects may not be reported. Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. Description and Brand Names. J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Adverse Side Effects. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Epub 2016 Aug 27. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 2019 Jun 13;15(6):e1007117. One of the adverse effects caused from imipenem therapy is seizures. This drug is ototoxic and nephrotoxic. Zeneca Pharmaceuticals, Wilmington, DE. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Cats are very susceptible to the vestibular effects of amikacin. Second-Generation Effects Lactation. Along with its needed effects, meropenem may cause some unwanted effects. Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." Although not all of these side effects may occur, if they do occur they may need medical attention. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. The pharmacokinetic parameters for meropenem are similar to those for imipenem/cilastatin, with the exception of meropenem's smaller volume of distribution. Dr. Susan, Veterinarian. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Cependant, certains patients, parents et soignants sont formés pour administrer MEROPENEM MYLAN 1 g, poudre …